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how many tramadol hcl 50 mg to get high Investigators reported a statistically significant increase in thenumber of patients on the test arm experiencing mild fever, chills,nausea, and diarrhea. These adverse events were generally mild, withthree patients on the test arm experiencing Grade 3 diarrhea; onepatient on the control arm and two on the test arm experiencing Grade 3nausea; and no reports, on either arm, of Grade 3 fever or chills (inthe absence of infection). There was an increase in the percentage ofpatients at each cycle with fever in the test arm (mean=27.2%,median=25.9%), versus the control arm (mean=5.3%, median=4.8%). Therewas also an increase in the percentage of patients at each cycle oftherapy exhibiting flu-like symptoms in the test arm (mean=87.9%,median=81.7%) versus the control arm (mean=47.3%, median=45%).